NASDAQ:AMLX

Amylyx Pharmaceuticals Stock Insider Trading

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$13.20
-0.0900 (-0.677%)
At Close: Jun 03, 2026

Amylyx Pharmaceuticals Stock Insider Power

Based on the 100 latest insides trades, we have calculated the insider power to be negative at -35.62. In total, the insiders bought 5.73M and sold 836.33K AMLX shares in the last 100 trades. The insider score can be negative despite buy/sell ratio being positive. The score focuses on the quality of the trades.

Insider Power

(Last 100 transactions)
-35.62
Buy 5.73M shares
Sell 836.33K shares
51% Buy Activity
Strong Negative Correlation
Buy Signal Low Confidence
Mar 05, 2026

Analysis Breakdown:

  • Signal is highly questionable due to a strongly contradictory negative Insider Power Score of -35.62.
  • Confidence increased due to high data reliability score of 100.

Historical Insider Trades

Date Type Person Role Amount
Mar 31, 2025
Sell
Common Stock
S-Sale
Cohen Joshua B
Co-chief Executive Officer
CEO / President 21 490
Value: $74.5K
Mar 31, 2025
Sell
Common Stock
S-Sale
Mazzariello Gina
Chief Legal Officer
Officer 9 192
Value: $32.0K
Mar 31, 2025
Sell
Common Stock
S-Sale
Bedrosian Camille L
Chief Medical Officer
Officer 12 425
Value: $43.1K
Mar 31, 2025
Sell
Common Stock
S-Sale
Frates James M
Chief Financial Officer
C-Suite Officer 10 896
Value: $37.8K
Mar 20, 2025
Buy
Common Stock
P-Purchase
Zeiher Bernhardt G
Director
Director 10 000
Value: $37.0K
Mar 20, 2025
Buy
Common Stock
P-Purchase
Zeiher Bernhardt G
Director
Director 10 000
Value: $37.0K
Mar 06, 2025
Buy
Common Stock
A-Award
Mazzariello Gina
Chief Legal Officer
Officer 63 851
Value: $230.5K
Mar 06, 2025
Buy
Stock Option (right to buy)
A-Award
Mazzariello Gina
Chief Legal Officer
Officer 95 777
Value: $345.8K
Mar 06, 2025
Buy
Common Stock
A-Award
Bedrosian Camille L
Chief Medical Officer
Officer 68 420
Value: $247.0K
Mar 06, 2025
Buy
Stock Option (Right to Buy)
A-Award
Bedrosian Camille L
Chief Medical Officer
Officer 102 630
Value: $370.5K
Mar 06, 2025
Buy
Common Stock
A-Award
Klee Justin B.
Co-chief Executive Officer
CEO / President 180 118
Value: $650.2K
Mar 06, 2025
Buy
Stock Option (right to buy)
A-Award
Klee Justin B.
Co-chief Executive Officer
CEO / President 270 177
Value: $975.3K
Mar 06, 2025
Buy
Common Stock
A-Award
Cohen Joshua B
Co-chief Executive Officer
CEO / President 180 118
Value: $650.2K
Mar 06, 2025
Buy
Stock Option (Right to Buy)
A-Award
Cohen Joshua B
Co-chief Executive Officer
CEO / President 270 177
Value: $975.3K
Mar 06, 2025
Buy
Common Stock
A-Award
Frates James M
Chief Financial Officer
C-Suite Officer 68 420
Value: $247.0K
Mar 06, 2025
Buy
Stock Option (right to buy)
A-Award
Frates James M
Chief Financial Officer
C-Suite Officer 102 630
Value: $370.5K
Mar 06, 2025
Buy
Stock Option (right to buy)
A-Award
Frates James M
Chief Financial Officer
C-Suite Officer 102 630
Value: $370.5K
Mar 06, 2025
Buy
Common Stock
A-Award
Frates James M
Chief Financial Officer
C-Suite Officer 68 420
Value: $247.0K
Mar 06, 2025
Buy
Stock Option (Right to Buy)
A-Award
Cohen Joshua B
Co-chief Executive Officer
CEO / President 270 177
Value: $975.3K
Mar 06, 2025
Buy
Common Stock
A-Award
Cohen Joshua B
Co-chief Executive Officer
CEO / President 180 118
Value: $650.2K
Mar 06, 2025
Buy
Stock Option (right to buy)
A-Award
Klee Justin B.
Co-chief Executive Officer
CEO / President 270 177
Value: $975.3K
Mar 06, 2025
Buy
Common Stock
A-Award
Klee Justin B.
Co-chief Executive Officer
CEO / President 180 118
Value: $650.2K
Mar 06, 2025
Buy
Stock Option (Right to Buy)
A-Award
Bedrosian Camille L
Chief Medical Officer
Officer 102 630
Value: $370.5K
Mar 06, 2025
Buy
Common Stock
A-Award
Bedrosian Camille L
Chief Medical Officer
Officer 68 420
Value: $247.0K
Mar 06, 2025
Buy
Stock Option (right to buy)
A-Award
Mazzariello Gina
Chief Legal Officer
Officer 95 777
Value: $345.8K

About Insider Power

Insider Power is a proprietary algorithm developed by StockInvest.us to evaluate the significance of insider transactions. The calculation considers the size, type, and timing of transactions, as well as the insider’s role within the company.

It is important to note that, in general, there is little to no correlation between insider transactions and short-term stock price movements. In one of our studies, only 0.22%* of stocks with insider activity showed a measurable correlation — and even then, it was unclear whether the effect was caused by insider actions or simply by the stock’s broader trend.

While our algorithms are designed to highlight potentially meaningful signals, these cannot be regarded as statistically significant on their own. Insider trading activity should therefore be seen as informative rather than as direct trading guidance. The Insider Power metric was created to present this information in a clearer and more accessible way, helping investors better understand the possible context of insider activity.

* October 6th, 2025 - Tested on 5562 stocks

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ABOUT AMYLYX PHARMACEUTICALS, INC.
Amylyx Pharmaceuticals
Amylyx Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, engages in developing various therapeutics for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The company's product pipeline includes AMX0035, a dual UPR-Bax apoptosis inhibitor composed of sodium phenylbutyrate and taurursodiol for the treatment of amyotrophic lateral sclerosis. It is also developing AMX0035 for other neurodegenerative diseases. ...
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