NASDAQ:SEPN

Septerna . Common Stock Stock Insider Trading

*Your capital is at risk

$38.85

+0.0200 (+0.0515%)

At Close: Aug 10, 2026

Septerna . Common Stock Stock Insider Power

Based on the 100 latest insides trades, we have calculated the insider power to be positive at 4.28. In total, the insiders bought 2.66M and sold 133.78K SEPN shares in the last 100 trades. The insider score can be negative despite buy/sell ratio being positive. The score focuses on the quality of the trades.

Insider Power (Last 100 transactions)	4.28
● Buy	2.66M shares
● Sell	133.78K shares
79% Buy Activity Moderate Negative Correlation
Sell Signal Low Confidence Mar 02, 2026 Analysis Breakdown: Weakened by a contradictory positive Insider Power Score. Partially supported by a negative historical correlation. Confidence increased due to high data reliability score of 100.

Historical Insider Trades

Date	Type	Person	Role	Amount
Jun 22, 2026 Buy	Common Stock M-Exempt	Long Daniel D. SVP, Drug Discovery	Officer	10 529 Value: $29.1K
Jun 22, 2026 Sell	Common Stock S-Sale	Long Daniel D. SVP, Drug Discovery	Officer	8 000 Value: $280.8K
Jun 22, 2026 Sell	Common Stock S-Sale	Long Daniel D. SVP, Drug Discovery	Officer	7 000 Value: $251.8K
Jun 22, 2026 Buy	Stock Option (Right to Buy) M-Exempt	Long Daniel D. SVP, Drug Discovery	Officer	4 471 Value: $52.3K
Jun 22, 2026 Buy	Stock Option (Right to Buy) M-Exempt	Long Daniel D. SVP, Drug Discovery	Officer	10 529 Value: $29.1K
Jun 12, 2026 Buy	Stock Option (Right to Buy) M-Exempt	Shaikhly Samira Chief People Officer	Officer	6 250 Value: $73.1K
Jun 12, 2026 Buy	Common Stock M-Exempt	Shaikhly Samira Chief People Officer	Officer	6 250 Value: $73.1K
Jun 12, 2026 Sell	Common Stock S-Sale	Shaikhly Samira Chief People Officer	Officer	6 250 Value: $219.2K
Jun 01, 2026 Buy	Stock Option (Right to Buy) M-Exempt	Shaikhly Samira Chief People Officer	Officer	4 355 Value: $7K
Jun 01, 2026 Buy	Common Stock M-Exempt	Shaikhly Samira Chief People Officer	Officer	637 Value: $2K
Jun 01, 2026 Buy	Common Stock M-Exempt	Shaikhly Samira Chief People Officer	Officer	943 Value: $3K
Jun 01, 2026 Buy	Common Stock M-Exempt	Shaikhly Samira Chief People Officer	Officer	4 355 Value: $7K
Jun 01, 2026 Sell	Common Stock S-Sale	Shaikhly Samira Chief People Officer	Officer	1 700 Value: $47.2K
Jun 01, 2026 Buy	Stock Option (Right to Buy) M-Exempt	Shaikhly Samira Chief People Officer	Officer	637 Value: $2K
Jun 01, 2026 Sell	Common Stock S-Sale	Shaikhly Samira Chief People Officer	Officer	1 346 Value: $38.8K
Jun 01, 2026 Buy	Stock Option (Right to Buy) M-Exempt	Shaikhly Samira Chief People Officer	Officer	943 Value: $3K
Jun 01, 2026 Sell	Common Stock S-Sale	Shaikhly Samira Chief People Officer	Officer	2 889 Value: $85.7K
May 26, 2026 Buy	Stock Option (Right to Buy) M-Exempt	Shaikhly Samira Chief People Officer	Officer	11 798 Value: $80.3K
May 26, 2026 Buy	Common Stock M-Exempt	Shaikhly Samira Chief People Officer	Officer	11 798 Value: $80.3K
May 26, 2026 Sell	Common Stock S-Sale	Shaikhly Samira Chief People Officer	Officer	11 798 Value: $354.7K
Apr 15, 2026 Buy	Common Stock M-Exempt	Bhatt Elizabeth President And COO	CEO / President	4 000 Value: $27.2K
Apr 15, 2026 Sell	Common Stock S-Sale	Bhatt Elizabeth President And COO	CEO / President	2 573 Value: $61.1K
Apr 15, 2026 Sell	Common Stock S-Sale	Bhatt Elizabeth President And COO	CEO / President	1 101 Value: $27.8K
Apr 15, 2026 Sell	Common Stock S-Sale	Bhatt Elizabeth President And COO	CEO / President	326 Value: $8K
Apr 15, 2026 Buy	Stock Option (Right to Buy) M-Exempt	Bhatt Elizabeth President And COO	CEO / President	4 000 Value: $27.2K

About Insider Power

Insider Power is a proprietary algorithm developed by StockInvest.us to evaluate the significance of insider transactions. The calculation considers the size, type, and timing of transactions, as well as the insider’s role within the company.

It is important to note that, in general, there is little to no correlation between insider transactions and short-term stock price movements. In one of our studies, only 0.22%^* of stocks with insider activity showed a measurable correlation — and even then, it was unclear whether the effect was caused by insider actions or simply by the stock’s broader trend.

While our algorithms are designed to highlight potentially meaningful signals, these cannot be regarded as statistically significant on their own. Insider trading activity should therefore be seen as informative rather than as direct trading guidance. The Insider Power metric was created to present this information in a clearer and more accessible way, helping investors better understand the possible context of insider activity.

* October 6th, 2025 - Tested on 5562 stocks