NASDAQ:SYRE

Spyre Therapeutics Stock Insider Trading

etoro logo Buy SYRE
*Your capital is at risk
$73.52
+4.36 (+6.30%)
At Close: Jun 03, 2026

Spyre Therapeutics Stock Insider Power

Based on the 100 latest insides trades, we have calculated the insider power to be negative at -57.87. In total, the insiders bought 3.93M and sold 405.48K SYRE shares in the last 100 trades. The insider score can be negative despite buy/sell ratio being positive. The score focuses on the quality of the trades.

Insider Power

(Last 100 transactions)
-57.87
Buy 3.93M shares
Sell 405.48K shares
51% Buy Activity
Moderate Negative Correlation
Sell Signal High Confidence
May 01, 2026

Analysis Breakdown:

  • Strongly supported by a very low Insider Power Score of -57.87.
  • Partially supported by a negative historical correlation.
  • Confidence increased due to high data reliability score of 100.

Historical Insider Trades

Date Type Person Role Amount
Jun 03, 2026
Buy
Stock Option (Right to Buy)
M-Exempt
Sloan Sheldon
Chief Medical Officer
Officer 8 333
Value: $228.8K
Jun 03, 2026
Buy
Common Stock
M-Exempt
Sloan Sheldon
Chief Medical Officer
Officer 8 333
Value: $228.8K
Jun 03, 2026
Sell
Common Stock
S-Sale
Sloan Sheldon
Chief Medical Officer
Officer 8 333
Value: $625.0K
Jun 01, 2026
Sell
Common Stock
S-Sale
Turtle Cameron
Chief Executive Officer
CEO / President 3 557
Value: $246.9K
Jun 01, 2026
Sell
Common Stock
S-Sale
Turtle Cameron
Chief Executive Officer
CEO / President 8 149
Value: $574.5K
Jun 01, 2026
Sell
Common Stock
S-Sale
Turtle Cameron
Chief Executive Officer
CEO / President 3 294
Value: $235.1K
Jun 01, 2026
Buy
Stock Option (Right to Buy)
M-Exempt
Burrows Scott L
Chief Financial Officer
C-Suite Officer 7 500
Value: $108.8K
Jun 01, 2026
Buy
Common Stock
M-Exempt
Burrows Scott L
Chief Financial Officer
C-Suite Officer 7 500
Value: $108.8K
Jun 01, 2026
Sell
Common Stock
S-Sale
Burrows Scott L
Chief Financial Officer
C-Suite Officer 1 801
Value: $125.6K
Jun 01, 2026
Sell
Common Stock
S-Sale
Burrows Scott L
Chief Financial Officer
C-Suite Officer 2 599
Value: $183.9K
Jun 01, 2026
Sell
Common Stock
S-Sale
Burrows Scott L
Chief Financial Officer
C-Suite Officer 3 100
Value: $223.4K
May 27, 2026
Buy
Stock Option (Right to Buy)
A-Award
Fairmount Funds Management Llc
Director
Director 8 026
Value: $582.0K
May 27, 2026
Buy
Stock Option (Right to Buy)
A-Award
Albers Jeffrey W.
Director
Director 8 026
Value: $582.0K
May 27, 2026
Buy
Stock Option (Right to Buy)
A-Award
Henderson Michael Thomas
Director
Director 8 026
Value: $582.0K
May 27, 2026
Buy
Stock Option (Right to Buy)
A-Award
Stelzer Laurie
Director
Director 8 026
Value: $582.0K
May 27, 2026
Buy
Stock Option (Right to Buy)
A-Award
Mckenna Mark C.
Director
Director 8 026
Value: $582.0K
May 27, 2026
Buy
Stock Option (Right to Buy)
A-Award
Milligan Sandra
Director
Director 8 026
Value: $582.0K
May 08, 2026
Sell
Common Stock
S-Sale
Henderson Michael Thomas
Director
Director 2 404
Value: $174.5K
May 08, 2026
Sell
Common Stock
S-Sale
Henderson Michael Thomas
Director
Director 33 513
Value: $2.47M
May 08, 2026
Sell
Common Stock
S-Sale
Henderson Michael Thomas
Director
Director 24 814
Value: $1.86M
May 08, 2026
Sell
Common Stock
S-Sale
Henderson Michael Thomas
Director
Director 19 269
Value: $1.45M
May 01, 2026
Buy
Stock Option (Right to Buy)
M-Exempt
Burrows Scott L
Chief Financial Officer
C-Suite Officer 12 500
Value: $181.3K
May 01, 2026
Buy
Common Stock
M-Exempt
Burrows Scott L
Chief Financial Officer
C-Suite Officer 12 500
Value: $181.3K
May 01, 2026
Sell
Common Stock
S-Sale
Burrows Scott L
Chief Financial Officer
C-Suite Officer 12 500
Value: $892.1K
May 01, 2026
Buy
Stock Option (Right to Buy)
M-Exempt
Sloan Sheldon
Chief Medical Officer
Officer 78 333
Value: $2.15M

About Insider Power

Insider Power is a proprietary algorithm developed by StockInvest.us to evaluate the significance of insider transactions. The calculation considers the size, type, and timing of transactions, as well as the insider’s role within the company.

It is important to note that, in general, there is little to no correlation between insider transactions and short-term stock price movements. In one of our studies, only 0.22%* of stocks with insider activity showed a measurable correlation — and even then, it was unclear whether the effect was caused by insider actions or simply by the stock’s broader trend.

While our algorithms are designed to highlight potentially meaningful signals, these cannot be regarded as statistically significant on their own. Insider trading activity should therefore be seen as informative rather than as direct trading guidance. The Insider Power metric was created to present this information in a clearer and more accessible way, helping investors better understand the possible context of insider activity.

* October 6th, 2025 - Tested on 5562 stocks

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