NASDAQ:KPTI

Karyopharm Therapeutics Stock Insider Trading

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$9.00
-0.230 (-2.49%)
At Close: Jun 03, 2026

Karyopharm Therapeutics Stock Insider Power

Based on the 100 latest insides trades, we have calculated the insider power to be positive at 3.82. In total, the insiders bought 753.98K and sold 51.37K KPTI shares in the last 100 trades. The insider score can be negative despite buy/sell ratio being positive. The score focuses on the quality of the trades.

Insider Power

(Last 100 transactions)
3.82
Buy 753.98K shares
Sell 51.37K shares
56% Buy Activity
Strong Negative Correlation
Sell Signal Low Confidence
Mar 02, 2026

Analysis Breakdown:

  • Weakened by a contradictory positive Insider Power Score.
  • Partially supported by a negative historical correlation.
  • Confidence increased due to high data reliability score of 100.

Historical Insider Trades

Date Type Person Role Amount
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Oliger Christy J.
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Mirza Mansoor Raza
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Greene Barry E
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Schor Chen
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Bohlin Garen G
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Bohlin Garen G
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Schor Chen
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Greene Barry E
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Mirza Mansoor Raza
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Oliger Christy J.
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Pakianathan Deepika
Director
Director 4 600
Value: $20.6K
May 28, 2025
Buy
Nonstatutory Stock Option (right to buy)
A-Award
Su Zhen
Director
Director 4 600
Value: $20.6K
May 06, 2025
Sell
Common Stock
S-Sale
Paulson Richard A.
President And CEO
CEO / President 236
Value: $2K
May 06, 2025
Sell
Common Stock
S-Sale
Paulson Richard A.
President And CEO
CEO / President 236
Value: $2K
Apr 23, 2025
Sell
Common Stock
S-Sale
Rangwala Reshma
EVP & Chief Medical Officer
Officer 419
Value: $3K
Apr 23, 2025
Sell
Common Stock
S-Sale
Rangwala Reshma
EVP & Chief Medical Officer
Officer 419
Value: $3K
Apr 04, 2025
Sell
Common Stock
S-Sale
Paulson Richard A.
President And CEO
CEO / President 245
Value: $916
Apr 04, 2025
Sell
Common Stock
S-Sale
Paulson Richard A.
President And CEO
CEO / President 245
Value: $916
Mar 04, 2025
Sell
Common Stock
S-Sale
Mano Michael
SVP, General Counsel&secretary
Officer 2 793
Value: $17.6K
Mar 04, 2025
Sell
Common Stock
S-Sale
Mano Michael
SVP, General Counsel&secretary
Officer 2 793
Value: $17.6K
Feb 28, 2025
Buy
Common Stock
A-Award
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
Officer 4 583
Value: $36.4K
Feb 28, 2025
Buy
Common Stock
A-Award
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
Officer 5 416
Value: $43.1K
Feb 28, 2025
Buy
Stock Option (right to buy)
A-Award
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
Officer 10 833
Value: $86.1K
Feb 28, 2025
Buy
Stock Option (right to buy)
A-Award
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
Officer 9 166
Value: $72.9K
Feb 28, 2025
Buy
Common Stock
A-Award
Rangwala Reshma
EVP & Chief Medical Officer
Officer 4 583
Value: $36.4K

About Insider Power

Insider Power is a proprietary algorithm developed by StockInvest.us to evaluate the significance of insider transactions. The calculation considers the size, type, and timing of transactions, as well as the insider’s role within the company.

It is important to note that, in general, there is little to no correlation between insider transactions and short-term stock price movements. In one of our studies, only 0.22%* of stocks with insider activity showed a measurable correlation — and even then, it was unclear whether the effect was caused by insider actions or simply by the stock’s broader trend.

While our algorithms are designed to highlight potentially meaningful signals, these cannot be regarded as statistically significant on their own. Insider trading activity should therefore be seen as informative rather than as direct trading guidance. The Insider Power metric was created to present this information in a clearer and more accessible way, helping investors better understand the possible context of insider activity.

* October 6th, 2025 - Tested on 5562 stocks

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ABOUT KARYOPHARM THERAPEUTICS INC.
Karyopharm Therapeutics
Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases. The company discovers, develops, and commercializes novel and Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1. Its lead compound, include XPOVIO in combination with bortezo...
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