NASDAQ:KPTI

Karyopharm Therapeutics Stock Insider Trading

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$9.00
-0.230 (-2.49%)
At Close: Jun 03, 2026

Karyopharm Therapeutics Stock Insider Power

Based on the 100 latest insides trades, we have calculated the insider power to be positive at 3.82. In total, the insiders bought 753.98K and sold 51.37K KPTI shares in the last 100 trades. The insider score can be negative despite buy/sell ratio being positive. The score focuses on the quality of the trades.

Insider Power

(Last 100 transactions)
3.82
Buy 753.98K shares
Sell 51.37K shares
56% Buy Activity
Strong Negative Correlation
Sell Signal Low Confidence
Mar 02, 2026

Analysis Breakdown:

  • Weakened by a contradictory positive Insider Power Score.
  • Partially supported by a negative historical correlation.
  • Confidence increased due to high data reliability score of 100.

Historical Insider Trades

Date Type Person Role Amount
May 21, 2026
Buy
Common Stock
A-Award
Greene Barry E
Director
Director 15 508
Value: $125.0K
May 21, 2026
Buy
Common Stock
A-Award
Bohlin Garen G
Director
Director 15 508
Value: $125.0K
May 21, 2026
Buy
Common Stock
A-Award
Su Zhen
Director
Director 15 508
Value: $125.0K
May 21, 2026
Buy
Common Stock
A-Award
Schor Chen
Director
Director 15 508
Value: $125.0K
May 21, 2026
Buy
Common Stock
A-Award
Pakianathan Deepika
Director
Director 15 508
Value: $125.0K
May 21, 2026
Buy
Common Stock
A-Award
Oliger Christy J.
Director
Director 15 508
Value: $125.0K
May 14, 2026
Sell
Common Stock
S-Sale
Mano Michael
EVP, Clo&secretary
Officer 266
Value: $3K
May 14, 2026
Sell
Common Stock
S-Sale
Paulson Richard A.
President And CEO
CEO / President 2 203
Value: $20.9K
May 14, 2026
Sell
Common Stock
S-Sale
Abate Kristin
Chief Accounting Officer
Officer 53
Value: $504
May 14, 2026
Sell
Common Stock
S-Sale
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
Officer 324
Value: $3K
May 14, 2026
Sell
Common Stock
S-Sale
Poulton Stuart
EVP, Chief Development Officer
Officer 403
Value: $4K
May 14, 2026
Sell
Common Stock
S-Sale
Rangwala Reshma
EVP & Chief Medical Officer
Officer 408
Value: $4K
May 13, 2026
Buy
Common Stock
A-Award
Mano Michael
EVP, Clo&secretary
Officer 700
Value: $6K
May 13, 2026
Buy
Common Stock
A-Award
Paulson Richard A.
President And CEO
CEO / President 4 920
Value: $43.5K
May 13, 2026
Buy
Common Stock
A-Award
Abate Kristin
Chief Accounting Officer
Officer 121
Value: $1K
May 13, 2026
Buy
Common Stock
A-Award
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
Officer 947
Value: $8K
May 13, 2026
Buy
Common Stock
A-Award
Poulton Stuart
EVP, Chief Development Officer
Officer 896
Value: $8K
May 13, 2026
Buy
Common Stock
A-Award
Rangwala Reshma
EVP & Chief Medical Officer
Officer 947
Value: $8K
Apr 21, 2026
Sell
Common Stock
S-Sale
Rangwala Reshma
EVP & Chief Medical Officer
Officer 449
Value: $4K
Mar 02, 2026
Sell
Common Stock
S-Sale
Mano Michael
EVP, Clo&secretary
Officer 3 526
Value: $33.2K
Mar 02, 2026
Sell
Common Stock
S-Sale
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
Officer 4 604
Value: $43.3K
Mar 02, 2026
Sell
Common Stock
S-Sale
Rangwala Reshma
EVP & Chief Medical Officer
Officer 5 066
Value: $47.7K
Mar 02, 2026
Sell
Common Stock
S-Sale
Paulson Richard A.
President And CEO
CEO / President 12 361
Value: $116.3K
Mar 02, 2026
Sell
Common Stock
S-Sale
Poulton Stuart
EVP, Chief Development Officer
Officer 5 101
Value: $48.0K
Feb 17, 2026
Sell
Common Stock
S-Sale
Poulton Stuart
EVP, Chief Development Officer
Officer 378
Value: $3K

About Insider Power

Insider Power is a proprietary algorithm developed by StockInvest.us to evaluate the significance of insider transactions. The calculation considers the size, type, and timing of transactions, as well as the insider’s role within the company.

It is important to note that, in general, there is little to no correlation between insider transactions and short-term stock price movements. In one of our studies, only 0.22%* of stocks with insider activity showed a measurable correlation — and even then, it was unclear whether the effect was caused by insider actions or simply by the stock’s broader trend.

While our algorithms are designed to highlight potentially meaningful signals, these cannot be regarded as statistically significant on their own. Insider trading activity should therefore be seen as informative rather than as direct trading guidance. The Insider Power metric was created to present this information in a clearer and more accessible way, helping investors better understand the possible context of insider activity.

* October 6th, 2025 - Tested on 5562 stocks

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ABOUT KARYOPHARM THERAPEUTICS INC.
Karyopharm Therapeutics
Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases. The company discovers, develops, and commercializes novel and Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1. Its lead compound, include XPOVIO in combination with bortezo...
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