NASDAQ:SPRO

Spero Therapeutics Stock Insider Trading

etoro logo Buy SPRO
*Your capital is at risk
$2.80
-0.0300 (-1.06%)
At Close: Jun 03, 2026

Spero Therapeutics Stock Insider Power

Based on the 100 latest insides trades, we have calculated the insider power to be negative at -37.48. In total, the insiders bought 5.69M and sold 1.25M SPRO shares in the last 100 trades. The insider score can be negative despite buy/sell ratio being positive. The score focuses on the quality of the trades.

Insider Power

(Last 100 transactions)
-37.48
Buy 5.69M shares
Sell 1.25M shares
50% Buy Activity
Moderate Positive Correlation
Sell Signal Medium Confidence
Feb 06, 2026

Analysis Breakdown:

  • Supported by a negative Insider Power Score of -37.48.
  • Partially supported by a positive historical correlation.
  • Confidence increased due to high data reliability score of 100.

Historical Insider Trades

Date Type Person Role Amount
Jun 12, 2025
Buy
Common Stock
A-Award
Tregoning Kathleen
Director
Director 20 000
Value: $57.8K
Jun 12, 2025
Buy
Common Stock
A-Award
Thomas Frank E
Director
Director 20 000
Value: $57.8K
Jun 12, 2025
Buy
Common Stock
A-Award
Smith Cynthia
Director
Director 20 000
Value: $57.8K
Jun 12, 2025
Buy
Common Stock
A-Award
Pottage John C Jr
Director
Director 20 000
Value: $57.8K
Jun 12, 2025
Buy
Common Stock
A-Award
Vink Patrick V.j.j.
Director
Director 20 000
Value: $57.8K
Jun 12, 2025
Buy
Common Stock
A-Award
Jackson Scott Thomas
Director
Director 20 000
Value: $57.8K
Jun 12, 2025
Buy
Common Stock
A-Award
Deshpande Milind
Director
Director 20 000
Value: $57.8K
Jun 12, 2025
Buy
Common Stock
A-Award
Mahadevia Ankit
Director
Director 20 000
Value: $57.8K
May 02, 2025
Buy
Common Stock
A-Award
Rajavelu Esther
See Remarks
Officer 185 000
Value: $119.7K
May 02, 2025
Buy
Common Stock
A-Award
Rajavelu Esther
See Remarks
Officer 185 000
Value: $119.7K
Feb 05, 2025
Sell
Common Stock
S-Sale
Keutzer Timothy
Chief Operating Officer
C-Suite Officer 3 974
Value: $3K
Feb 05, 2025
Sell
Common Stock
S-Sale
Keutzer Timothy
Chief Operating Officer
C-Suite Officer 27 643
Value: $21.6K
Feb 05, 2025
Sell
Common Stock
S-Sale
Keutzer Timothy
Chief Operating Officer
C-Suite Officer 24 920
Value: $19.4K
Feb 05, 2025
Sell
Common Stock
S-Sale
Rajavelu Esther
CFO & Cbo
C-Suite Officer 20 689
Value: $16.1K
Feb 05, 2025
Sell
Common Stock
S-Sale
Shukla Sath
CEO & President
CEO / President 6 139
Value: $5K
Feb 05, 2025
Sell
Common Stock
S-Sale
Shukla Sath
CEO & President
CEO / President 42 786
Value: $33.4K
Feb 05, 2025
Sell
Common Stock
S-Sale
Shukla Sath
CEO & President
CEO / President 106 408
Value: $83.0K
Feb 05, 2025
Sell
Common Stock
S-Sale
Mahadevia Ankit
Director
Director 13 959
Value: $10.9K
Feb 05, 2025
Sell
Common Stock
S-Sale
Mahadevia Ankit
Director
Director 55 260
Value: $43.1K
Feb 05, 2025
Sell
Common Stock
S-Sale
Mahadevia Ankit
Director
Director 55 260
Value: $43.1K
Feb 05, 2025
Sell
Common Stock
S-Sale
Mahadevia Ankit
Director
Director 13 959
Value: $10.9K
Feb 05, 2025
Sell
Common Stock
S-Sale
Shukla Sath
CEO & President
CEO / President 106 408
Value: $83.0K
Feb 05, 2025
Sell
Common Stock
S-Sale
Shukla Sath
CEO & President
CEO / President 42 786
Value: $33.4K
Feb 05, 2025
Sell
Common Stock
S-Sale
Shukla Sath
CEO & President
CEO / President 6 139
Value: $5K
Feb 05, 2025
Sell
Common Stock
S-Sale
Rajavelu Esther
CFO & Cbo
C-Suite Officer 20 689
Value: $16.1K

About Insider Power

Insider Power is a proprietary algorithm developed by StockInvest.us to evaluate the significance of insider transactions. The calculation considers the size, type, and timing of transactions, as well as the insider’s role within the company.

It is important to note that, in general, there is little to no correlation between insider transactions and short-term stock price movements. In one of our studies, only 0.22%* of stocks with insider activity showed a measurable correlation — and even then, it was unclear whether the effect was caused by insider actions or simply by the stock’s broader trend.

While our algorithms are designed to highlight potentially meaningful signals, these cannot be regarded as statistically significant on their own. Insider trading activity should therefore be seen as informative rather than as direct trading guidance. The Insider Power metric was created to present this information in a clearer and more accessible way, helping investors better understand the possible context of insider activity.

* October 6th, 2025 - Tested on 5562 stocks

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ABOUT SPERO THERAPEUTICS INC.
Spero Therapeutics
Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adults; SPR206, a direct actin...
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