NASDAQ:IONS

Ionis Pharmaceuticals Stock Insider Trading

Healthcare > Biotechnology

Buy IONS

*Your capital is at risk

$73.82

+0.85 (+1.16%)

At Close: Jun 03, 2026

Ionis Pharmaceuticals Stock Insider Power

Based on the 100 latest insides trades, we have calculated the insider power to be negative at -80.29. In total, the insiders bought 915.22K and sold 556.14K IONS shares in the last 100 trades. The insider score can be negative despite buy/sell ratio being positive. The score focuses on the quality of the trades.

Insider Power (Last 100 transactions)	-80.29
● Buy	915.22K shares
● Sell	556.14K shares
66% Buy Activity Strong Negative Correlation
Sell Signal High Confidence Jan 16, 2026 Analysis Breakdown: Strongly supported by a very low Insider Power Score of -80.29. Partially supported by a negative historical correlation. Confidence increased due to high data reliability score of 100.

Historical Insider Trades

Date	Type	Person	Role	Amount
Mar 16, 2026 Buy	Non-Qualified Stock Option (right to buy) M-Exempt	Hougen Elizabeth L EVP, Finance & CFO	C-Suite Officer	20 541 Value: $771.9K
Mar 16, 2026 Sell	Common Stock S-Sale	Hougen Elizabeth L EVP, Finance & CFO	C-Suite Officer	9 440 Value: $686.9K
Mar 16, 2026 Sell	Common Stock S-Sale	Hougen Elizabeth L EVP, Finance & CFO	C-Suite Officer	205 608 Value: $14.9M
Mar 16, 2026 Buy	Common Stock M-Exempt	Hougen Elizabeth L EVP, Finance & CFO	C-Suite Officer	61 041 Value: $3.47M
Mar 16, 2026 Buy	Common Stock M-Exempt	Hougen Elizabeth L EVP, Finance & CFO	C-Suite Officer	60 299 Value: $3.67M
Mar 04, 2026 Sell	Common Stock S-Sale	Loscalzo Joseph Director	Director	200 Value: $16.0K
Mar 04, 2026 Buy	Common Stock M-Exempt	Baroldi Joseph EVP, Chief Business Officer	Officer	238 Value: $13.5K
Mar 04, 2026 Buy	Common Stock M-Exempt	Loscalzo Joseph Director	Director	200 Value: $8K
Mar 03, 2026 Buy	Non-Qualified Stock Option (right to buy) M-Exempt	Loscalzo Joseph Director	Director	832 Value: $31.7K
Mar 03, 2026 Sell	Common Stock S-Sale	Loscalzo Joseph Director	Director	832 Value: $66.8K
Mar 03, 2026 Buy	Common Stock M-Exempt	Devers Shannon L. EVP, Chief Human Resources Ofc	Officer	385 Value: $20.4K
Mar 03, 2026 Buy	Non-Qualified Stock Option (right to buy) M-Exempt	Diaz Allene M. Director	Director	10 321 Value: $424.0K
Mar 03, 2026 Buy	Non-Qualified Stock Option (right to buy) M-Exempt	Diaz Allene M. Director	Director	18 000 Value: $720.9K
Mar 03, 2026 Buy	Non-Qualified Stock Option (right to buy) M-Exempt	Diaz Allene M. Director	Director	12 000 Value: $456.7K
Mar 03, 2026 Sell	Common Stock S-Sale	Diaz Allene M. Director	Director	1 005 Value: $81.2K
Mar 03, 2026 Sell	Common Stock S-Sale	Diaz Allene M. Director	Director	14 608 Value: $1.17M
Mar 03, 2026 Sell	Common Stock S-Sale	Diaz Allene M. Director	Director	39 265 Value: $3.11M
Mar 03, 2026 Sell	Common Stock S-Sale	Bennett C Frank EVP, Chief Scientific Officer	Officer	12 687 Value: $1.01M
Mar 03, 2026 Sell	Common Stock S-Sale	Bennett C Frank EVP, Chief Scientific Officer	Officer	71 600 Value: $5.66M
Mar 03, 2026 Buy	Common Stock M-Exempt	Bennett C Frank EVP, Chief Scientific Officer	Officer	16 463 Value: $536.7K
Mar 03, 2026 Buy	Common Stock M-Exempt	Bennett C Frank EVP, Chief Scientific Officer	Officer	48 626 Value: $2.96M
Mar 03, 2026 Buy	Non-Qualified Stock Option (right to buy) M-Exempt	Devers Shannon L. EVP, Chief Human Resources Ofc	Officer	6 951 Value: $226.6K
Mar 03, 2026 Sell	Common Stock S-Sale	Baroldi Joseph EVP, Chief Business Officer	Officer	4 096 Value: $325.1K
Mar 03, 2026 Buy	Non-Qualified Stock Option (right to buy) M-Exempt	Bennett C Frank EVP, Chief Scientific Officer	Officer	48 626 Value: $2.96M
Mar 03, 2026 Buy	Non-Qualified Stock Option (right to buy) M-Exempt	Bennett C Frank EVP, Chief Scientific Officer	Officer	16 463 Value: $536.7K

About Insider Power

Insider Power is a proprietary algorithm developed by StockInvest.us to evaluate the significance of insider transactions. The calculation considers the size, type, and timing of transactions, as well as the insider’s role within the company.

It is important to note that, in general, there is little to no correlation between insider transactions and short-term stock price movements. In one of our studies, only 0.22%^* of stocks with insider activity showed a measurable correlation — and even then, it was unclear whether the effect was caused by insider actions or simply by the stock’s broader trend.

While our algorithms are designed to highlight potentially meaningful signals, these cannot be regarded as statistically significant on their own. Insider trading activity should therefore be seen as informative rather than as direct trading guidance. The Insider Power metric was created to present this information in a clearer and more accessible way, helping investors better understand the possible context of insider activity.

* October 6th, 2025 - Tested on 5562 stocks

ABOUT IONIS PHARMACEUTICALS

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It also develops medicines for various...

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