NASDAQ:IONS

Ionis Pharmaceuticals Stock Insider Trading

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*Your capital is at risk
$72.97
-2.41 (-3.20%)
At Close: Jun 02, 2026

Ionis Pharmaceuticals Stock Insider Power

Based on the 100 latest insides trades, we have calculated the insider power to be negative at -80.29. In total, the insiders bought 915.22K and sold 556.14K IONS shares in the last 100 trades. The insider score can be negative despite buy/sell ratio being positive. The score focuses on the quality of the trades.

Insider Power

(Last 100 transactions)
-80.29
Buy 915.22K shares
Sell 556.14K shares
66% Buy Activity
Strong Negative Correlation
Sell Signal High Confidence
Jan 16, 2026

Analysis Breakdown:

  • Strongly supported by a very low Insider Power Score of -80.29.
  • Partially supported by a negative historical correlation.
  • Confidence increased due to high data reliability score of 100.

Historical Insider Trades

Date Type Person Role Amount
May 14, 2026
Buy
Common Stock
M-Exempt
Monia Brett P
Chief Executive Officer
CEO / President 3 220
Value: $105.0K
May 14, 2026
Sell
Common Stock
S-Sale
Monia Brett P
Chief Executive Officer
CEO / President 3 220
Value: $253.3K
May 14, 2026
Buy
Non-Qualified Stock Option (right to buy)
M-Exempt
Monia Brett P
Chief Executive Officer
CEO / President 3 220
Value: $105.0K
May 13, 2026
Buy
Common Stock
M-Exempt
Monia Brett P
Chief Executive Officer
CEO / President 1 316
Value: $42.9K
May 13, 2026
Sell
Common Stock
S-Sale
Monia Brett P
Chief Executive Officer
CEO / President 1 316
Value: $102.7K
May 13, 2026
Buy
Non-Qualified Stock Option (right to buy)
M-Exempt
Monia Brett P
Chief Executive Officer
CEO / President 1 316
Value: $42.9K
May 04, 2026
Buy
Non-Qualified Stock Option (right to buy)
M-Exempt
Loscalzo Joseph
Director
Director 16 000
Value: $686.1K
May 04, 2026
Buy
Common Stock
M-Exempt
Loscalzo Joseph
Director
Director 12 000
Value: $722.4K
May 04, 2026
Buy
Non-Qualified Stock Option (right to buy)
M-Exempt
Loscalzo Joseph
Director
Director 12 000
Value: $722.4K
May 04, 2026
Buy
Non-Qualified Stock Option (right to buy)
M-Exempt
Loscalzo Joseph
Director
Director 16 000
Value: $1.04M
May 04, 2026
Sell
Common Stock
S-Sale
Loscalzo Joseph
Director
Director 17 781
Value: $1.34M
May 04, 2026
Buy
Non-Qualified Stock Option (right to buy)
M-Exempt
Loscalzo Joseph
Director
Director 12 000
Value: $480.6K
May 04, 2026
Buy
Non-Qualified Stock Option (right to buy)
M-Exempt
Loscalzo Joseph
Director
Director 10 968
Value: $417.4K
May 04, 2026
Buy
Non-Qualified Stock Option (right to buy)
M-Exempt
Loscalzo Joseph
Director
Director 10 321
Value: $424.0K
May 04, 2026
Buy
Common Stock
M-Exempt
Loscalzo Joseph
Director
Director 10 321
Value: $424.0K
May 04, 2026
Buy
Common Stock
M-Exempt
Loscalzo Joseph
Director
Director 12 000
Value: $480.6K
May 04, 2026
Sell
Common Stock
S-Sale
Loscalzo Joseph
Director
Director 59 508
Value: $4.46M
May 04, 2026
Buy
Common Stock
M-Exempt
Loscalzo Joseph
Director
Director 10 968
Value: $417.4K
May 04, 2026
Buy
Common Stock
M-Exempt
Loscalzo Joseph
Director
Director 16 000
Value: $686.1K
May 04, 2026
Buy
Common Stock
M-Exempt
Loscalzo Joseph
Director
Director 16 000
Value: $1.04M
May 01, 2026
Buy
Common Stock
M-Exempt
Klein Joseph Iii
Director
Director 10 111
Value: $476.3K
May 01, 2026
Sell
Common Stock
S-Sale
Klein Joseph Iii
Director
Director 8 680
Value: $636.7K
May 01, 2026
Sell
Common Stock
S-Sale
Klein Joseph Iii
Director
Director 1 431
Value: $106.5K
May 01, 2026
Buy
Non-Qualified Stock Option (right to buy)
M-Exempt
Klein Joseph Iii
Director
Director 10 111
Value: $476.3K
Apr 28, 2026
Sell
Common Stock
S-Sale
Baroldi Joseph
EVP, Chief Business Officer
Officer 1 626
Value: $116.7K

About Insider Power

Insider Power is a proprietary algorithm developed by StockInvest.us to evaluate the significance of insider transactions. The calculation considers the size, type, and timing of transactions, as well as the insider’s role within the company.

It is important to note that, in general, there is little to no correlation between insider transactions and short-term stock price movements. In one of our studies, only 0.22%* of stocks with insider activity showed a measurable correlation — and even then, it was unclear whether the effect was caused by insider actions or simply by the stock’s broader trend.

While our algorithms are designed to highlight potentially meaningful signals, these cannot be regarded as statistically significant on their own. Insider trading activity should therefore be seen as informative rather than as direct trading guidance. The Insider Power metric was created to present this information in a clearer and more accessible way, helping investors better understand the possible context of insider activity.

* October 6th, 2025 - Tested on 5562 stocks

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ABOUT IONIS PHARMACEUTICALS
Ionis Pharmaceuticals
Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It also develops medicines for various...
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